Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4812 | CA11865 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 110 |
| 2 | AZT+DDI | 40 |
| 3 | 3TC+AZT | 94 |
| 4 | DLV+NFV+SQV | 111 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | Q58E, G73S | L10V, I13V, F53Y, L63P, V77I |
| >CA11865| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGYIKVREYD QIPIEICGHKAISTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W | T215C | K103N | E6D, V35M, T39A, K43E, I50V, V111I, D123E, I142V, D177E, I178L, H208Y, R211K, L228H, A272P, K277R, T286A, I293V | E40C |
| >CA11714| codons 1-303 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICACLEEEGKISKVGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFCTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |