Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4797 | CA11845 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 61 |
| 2 | None | 57 |
| 3 | 3TC+IDV | 22 |
| 4 | 3TC+AZT+IDV | 151 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F | L5LF, L10I, L19Q, K20T, K43KN, I64V, A71V, V77I, I85V, I93L | D25DV |
| >CA11845| codons 1-99 PQITFWQRPIVTIKIGGQQTEALLVTGADDTVLEEMNLPGRWNPKIIGGIGGFVKVRQYD QILVEICGHKVIGTVLIGPTPFNIVGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215Y | E44D, K122E, T200I, Q207A, R211K, V245M, E248D, D250E, R284K | Q269QE, I270IL, K281KE, T286R |
| >CA11694| codons 1-286 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRAHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPDKESWTVNDIQKLVGKLNWASELYAGIKVKQLCELLKGR |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |