Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4766 | CA11796 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | NRTI | NA |
| 3 | 3TC+D4T+IDV | 104 |
| 4 | D4T+DDI+RTV+SQV | 65 |
| 5 | D4T+DDI+NVP+RTV+SQV | 15 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73S, N83ND | L10I, A22V, E35G, M36I, N37D, R41K, I62V, L63P, C67F, H69R, A71V, I72R, V77I, I93L |
| >CA11796| codons 1-99 PQITLWQRPIVTIKIGGQLKEVLLDTGADDTVLEGIDLPGKWKPKIIGGIGGFIKVRQYD QVPIEIFGRKVRSTVLIGPTPVDIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215F | K219Q | Y181C, G190A | K20R, V35I, K102N, D121Y, K122E, I135V, I142V, S162D, I178L, E203K, Q207D, H208Y, R211K, L228H, V245K, A272P |
| >CA11654| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKNKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDLVI CQYMDDLYVASDLEIGQHRTKIKELRDYLWKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |