Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4749 | CA11781 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC+IDV | 144 |
| 2 | D4T+DDI+EFV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | L10I, L19I, L63P, I64V, I93L |
| >CA11781| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGHKAIGTVLVGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K103N, G190A | V35I, R83K, K122E, A158S, T165I, R211K, D218E, K249Q, A272P, R284K, T286A, V292I, I293V, A304G |
| >CA11624| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMIKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEIVPLTEEAE LELG |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |