Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3979 | CA11780 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 161 |
| 2 | 3TC+AZT+IDV | 13 |
| 3 | 3TC+AZT+SQV | 26 |
| 4 | 3TC+AZT+NFV | 65 |
| 5 | 3TC+DDI+NVP+RTV+SQV | 45 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84IV, L90M | N88ND | K20I, E35G, M36I, I62V, L63P, H69NT, A71X, I72V, T74TS |
| >CA11780| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEGINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGNKXVGSVLVGPTPVNVIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74I, M184V | K103KN | K20R, T69N, R83K, K122E, D123E, D177E, I178M, F214L, V245E, A272P, E297K |
| >CA24745| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSNRWRKIVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |