Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1490 | CA11774 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 82 |
| 2 | D4T | 57 |
| 3 | 3TC+AZT | 26 |
| 4 | 3TC+AZT+IDV | 22 |
| 5 | 3TC+D4T+IDV | 35 |
| 6 | DDI+DLV+NFV | 17 |
| 7 | D4T+RTV+SQV | 38 |
| 8 | 3TC+D4T+NFV+SQV | 40 |
| 9 | 3TC+ABC+D4T+NFV+SQV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | K43T, F53L, L89V | L10V, I13IV, M36I, N37D, K55KR, L63P, A71V | K20RS |
| >CA11774| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTILEEIDLPGRWTPKIIGGIGGLIRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, M184V, T215Y | K219Q | K103KN | K20R, V106I, I135V, G196E, R211T, F214L, H221Y, I293V |
| >CA11616| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLTWGLYTPDQKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |