<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
HMDR-1 1-1096 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 156
2 AZT+DDI 73
3 AZT+DDC 135
4 3TC+AZT 52
5 D4T+DDI 21
6 D4T+DDI+SQV 30
7 3TC+D4T+SQV 13
8 3TC+AZT+IDV 17
9 D4T+DDI+RTV+SQV 8

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A   L10I, L63H, A71V, V77I  
>1-1096| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFTKVRQYD
QIHIEICGHKVIGTVLIGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y       V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D  
>1-1096| codons 26-245
LTEEKIKALIEICTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQ
DFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQ
YNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRTKIEEF
RQYLWKWGFYTPDKKHQKDPPFLWMGYELHPDKWTVQPIV

References
Author Title Citation
Shafer, RW Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. Ann Intern Med, 1998
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005