Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| HMDR-4 | 4 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDC | 104 |
| 3 | DDI | 21 |
| 4 | AZT+DDI | 30 |
| 5 | D4T | 52 |
| 6 | 3TC+AZT | 21 |
| 7 | 3TC+AZT+SQV | 30 |
| 8 | 3TC+AZT+RTV+SQV | 39 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82A, L90M | I84IM | L10LI, N37D, L63P, A71L, V77I, I93L |
| >4| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIVGIGGFTKVRQYD QIPIEICGHKLIGTVLIGPTPANMIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | A98G | K43E, E44A, K64R, R83K, V118I, S163C, G196E, H208Y, R211K, D218E | Q161P |
| >4| codons 1-250 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIRKKNSTKWRKIVDFRELNKKTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFPSCMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKD |
References
| Author | Title | Citation |
| Shafer, RW | Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. | Ann Intern Med, 1998 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |