Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| HMDR-3 | 3-1196 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 86 |
| 3 | SQV | 25 |
| 4 | 3TC+AZT+DDI | 43 |
| 5 | 3TC+D4T+IDV | 21 |
| 6 | RTV+SQV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, R41K, Q61H, L63Q, A71V, T74A, V77I, I93L |
| >3-1196| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIVGIGGFTKVRQYD HIQIEICGHKVIGAVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V35I, K43N, V60I, A98S, V118I, K122X, I135V, K154X, G196E, Q207E, R211K, V245M |
| >3-1196| codons 26-245 LTEEKIKALIEICTELENEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQ DFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPLDXDFRKYTAFTIPSVNNETPGIRYQ YNVLPQGWXGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRTKIEEL REHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIM |
References
| Author | Title | Citation |
| Shafer, RW | Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. | Ann Intern Med, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |