Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| HMDR-2 | 2-197 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | AZT+DDI | 52 |
| 3 | AZT+DDC | 52 |
| 4 | DDC+SQV | 21 |
| 5 | 3TC+DDC+SQV | 30 |
| 6 | 3TC+D4T+DDC+SQV | 52 |
| 7 | 3TC+D4T+DDC+RTV | 21 |
| 8 | D4T+DDI+IDV+SQV | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | T39K, K43E, E44D, V60I, K102Q, V118I, K122E, Q207E, R211K, V245E |
| >2-197| codons 26-245 LTEEKIKALVEICKELEEDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQ DFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQ YNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEEL REHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, N37T, R41K, I62V, L63P, H69Y, A71V, T74S, V77I |
| >2-197| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMTLPGKWKPKMIVGIGGFTKVRQYD QVPIEICGYKVIGSVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Shafer, RW | Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. | Ann Intern Med, 1998 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |