Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| HMDR-1 | 1-896-6B | U.S. | 1996 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | AZT+DDI | 73 |
| 3 | AZT+DDC | 135 |
| 4 | 3TC+AZT | 52 |
| 5 | D4T+DDI | 21 |
| 6 | D4T+DDI+SQV | 30 |
| 7 | 3TC+D4T+SQV | 13 |
| 8 | 3TC+AZT+IDV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, L63H, A71V, V77I |
| >1-896-6B| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFTKVRQYD QIHIEICGHKVIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K20R, V21I, V35I, K43E, E44A, K102Q, V118I, K122E, I135T, G196E, L205F, H208Y, R211K, E224D, A272P, I293V |
| >1-896-6B| codons 1-303 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEEFRQYLWKWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Shafer, RW | Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance of HIV-1 isolates from heavily treated patients. | Ann Intern Med, 1998 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |