Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-5577 | P5577-906 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ D4T | 76 |
| 2 | 3TC+ DDC+ IDV | 44 |
| 3 | DDC+ RTV+ SQV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, K14R, N37Y, R41K, I62V, L63P, V77I |
| >P5577-906| codons 1-92 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMYLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKAISTVLIGPTPVNVIGRNLMTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K122E, I135V, S162G, E203D, Q207D, R211K |
| >P5577-906| codons 31-236 IKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEV QLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLP QGWKGSPAIFQGSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIDELRDHLW KWGFYTPDKKHQKEPPFLWMGYELHP |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |