Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-4651 | P4651-319 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 20 |
| 2 | 3TC+ AZT | 38 |
| 3 | 3TC+ D4T | 12 |
| 4 | 3TC+ DDI+ IDV | 11 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33I | N37S, I62V, L63S, I64L, A71V, V77I |
| >P4651-319| codons 1-92 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYD QVSLEICGHKVIGTVLIGPTPVNIIGRNLLTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219N | V35M, T39A, K43E, E44D, D123E, K166R, D177E, I202V, E203D, H208Y, R211K |
| >P4651-319| codons 30-237 KIKALMEICAELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWE VQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVL PQGWKGSPAIFQSSMTRILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRTKVDELRQYL WKWGFYTPDNKHQKEPPFLWMGYELHPD |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |