Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-4520 | P4520-1146 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | NRTI | 186 |
| 3 | 3TC+ AZT | 8 |
| 4 | 3TC+ D4T+ IDV | 81 |
| 5 | 3TC+ AZT+ IDV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, N37S, K45R, I62V, L63T, V77I |
| >P4520-1146| codons 1-92 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPRMIGGIGGFIKVRQYD QVTIEICGHKAIGTVLIGPTPVNIIGRNLLTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K122E, I135T, I178M, R211S |
| >P4520-1146| codons 30-236 KIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWE VQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVL PQGWKGSPAIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIGQHRTKIEELRQHL LSWGFTTPDKKHQKEPPFLWMGYELHP |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |