Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3926 | P3926-732 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC | 12 |
| 2 | 3TC+ AZT | 49 |
| 3 | 3TC+ AZT+ SQV | 22 |
| 4 | 3TC+ D4T+ IDV | 6 |
| 5 | DDI+ RTV+ SQV | 19 |
| 6 | D4T+ DDC+ NFV+ NVP | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A | L10I, I15V, Q18IL, M36I, N37D, I62V, L63Q, A71V, T74S, I93X |
| >P3926-732| codons 1-93 PQITLWQRPIVTIKVGGILKEALLDTGADDTVLEEIDLPGRWKPKMIVGIGGFVKVRQYD QVQIEICGHKVIGSVLVGPTPANIIGRNLLTQF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | Y181C, G190A | E44D, V118I, K122E, S162C, R211K, L228R |
| >P3926-732| codons 31-236 IKALVEICTELEKDGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEV QLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLP QGWKGSPAIFQCSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRQHLW KWGFYTPDRKHQKEPPFRWMGYELHP |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |