Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-3395 | P3395-1753 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 6 |
| 2 | NRTI | 24 |
| 3 | 3TC+ AZT+ IDV | 51 |
| 4 | D4T+ RTV+ SQV | 30 |
| 5 | D4T+ DDI+ NFV+ NVP | 4 |
| 6 | 3TC+ D4T+ DDI+ NFV | 40 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | L5X, L10I, L19I, E35D, N37D, L63P, I64V, V77I, I93L |
| >P3395-1753| codons 1-99 PQITXWQRPIVTIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGHKAIGTVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K122E, T165L, I167X, E169X, I178M, K201T, R211K |
| >P3395-1753| codons 22-233 KQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELN KRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPG IRYQYNVLPQGWKGSPAIFQSSMLKMLDPFRKQNPDMVIYQYVDDLYVGSDLEIGQHRTT IEELRQHLLKWGFYTPDKKHQKEPPFLWMGYE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |