Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-0503 | P503-710 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 82 |
| 2 | NRTI | 132 |
| 3 | AZT+ DDC | 20 |
| 4 | AZT+ DDI | 9 |
| 5 | 3TC+ AZT+ RTV | 60 |
| 6 | 3TC+ D4T+ SQV | 8 |
| 7 | 3TC+ IDV+ NVP | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | L10I, K20R, E35D, M36I, N37S, I62V, L63P, A71T, V77I |
| >P503-710| codons 7-92 QRPIVTIKIGGQLREALLDTGADDTVLEDISLPGRWKPKMIGGIGGFVKVRQYDQVPIEI CGHKTIGTVLIGPTPVNIIGRNLMTQ |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | Y181C | A98G | K43E, V60I, R83K, K122E, D218E |
| >P503-710| codons 41-238 LEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGL KKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF QSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPEKK HQKEPPFLWMGYELHPDK |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |