Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-6459 | P6459-1140 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ IDV | 14 |
| 2 | 3TC+ NFV+ NVP | 22 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | Y181C | V60I, I135V, E169D, R211K | Q182Q* |
| >P6459-1140| codons 30-234 KIKALVEICTEMEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWE VQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVL PQGWKGSPAIFQSSMTKILDPFRKQNPDIVIC*YVDDLYVGSDLEIGQHRTKIEELRQHL LKWGFTTPDEKHQKEPPFLWMGYEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19I, M46X |
| >P6459-1140| codons 1-91 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLT |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |