Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4572 | CA11198 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 65 |
| 2 | 3TC+D4T+NFV | 26 |
| 3 | 3TC+AZT+NVP | 90 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | G190A | V35IM, K101R, K122E, D123N, T139R, S162C, T200A, E204D, Q207G, K223Q, V245Q |
| >CA11198| codons 1-251 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNERPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRAKIEDLRGHLLRWGFFTPDQKHQQEPPFLWMGYELHPDKWT VQPIQLPEKDS |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, L19LQ, E35D, N37DE, L63AP, A71T |
| >CA11223| codons 1-99 PQITLWQRPIVTIKIGGQQKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QIAIEICGHKTIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive value of HIV-1 genotypic resistance test interpretation algorithms. | J Infect Dis, 2009 |