<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4516 CA11105 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT 5
2 3TC+AZT+SQV 6
3 3TC+AZT+IDV 9
4 3TC+D4T+IDV 101
5 NVP+DDI+NFV 7
6 DLV+DDI+NFV 29
7 EFV+DDI+NFV 22

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L24I, K43T L10I, V11VL, D60N, L63P, A71V, I93L  
>CA11105| codons 1-99
PQITLWQRPILTIKIGGQLKEALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVKVRQYN
QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, M184V   K103N, Y181C V108I A98S, D123E, I135L, I142V, M164MI, E169X, I178L, V179I, V189I, G196E, T200A, R211K, H221Y, L228LF, A272T, T286A, V292I, E297K F171FS
>CA11006| codons 1-303
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSVPL
DKEFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSITKILXPSRKQNPDLII
CQYVDDLYIGSDLEIEQHRAKIEELRQHLLKWGFTTPDKKYQKEPPFFWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGAKALTEIIPLTKEAE
LEL

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005