Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4516 | CA11105 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 5 |
| 2 | 3TC+AZT+SQV | 6 |
| 3 | 3TC+AZT+IDV | 9 |
| 4 | 3TC+D4T+IDV | 101 |
| 5 | NVP+DDI+NFV | 7 |
| 6 | DLV+DDI+NFV | 29 |
| 7 | EFV+DDI+NFV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, K43T | L10I, V11VL, D60N, L63P, A71V, I93L |
| >CA11105| codons 1-99 PQITLWQRPILTIKIGGQLKEALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVKVRQYN QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | K103N, Y181C | V108I | A98S, D123E, I135L, I142V, M164MI, E169X, I178L, V179I, V189I, G196E, T200A, R211K, H221Y, L228LF, A272T, T286A, V292I, E297K | F171FS |
| >CA11006| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSITKILXPSRKQNPDLII CQYVDDLYIGSDLEIEQHRAKIEELRQHLLKWGFTTPDKKYQKEPPFFWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGAKALTEIIPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |