Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1466 | CA11103 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 217 |
| 2 | AZT+ DDI | 8 |
| 3 | 3TC+ D4T | 34 |
| 4 | 3TC+ D4T+ NFV | 60 |
| 5 | EFV+ ADV | 18 |
| 6 | EFV+ ADV+ NFV | 13 |
| 7 | EFV+ RTV+ IDV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73C | K20V, N37S, R41K, I62IV, L63P, I64V, T74S, V77I |
| >CA11103| codons 1-99 PQITLWQRPLVTIKIGGQLVEALLDTGADDTVLEEMSLPGKWKPKIIGGIGGFIKVRQYD QVPVEICGHKAICSVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N, Y188YC | P225PH | E6K, K20KR, V35M, K64R, D86E, L100X, K122E, I135T, S162SY, G196K, T200I, F227FY, I257L, A272P, T286A, I293V, E297K |
| >CA11012| codons 1-303 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIRKKDSTKWRKLVDFRELNKRTQEFWEVQLGIPHPAGXKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLCVGSDLEIKQHRIKIEELRQHLLRWGFTTPDKKHQKEHPYLWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |