Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1556 | CA11045 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 109 |
| 2 | AZT+DDC | 14 |
| 3 | DDI | 27 |
| 4 | D4T | 21 |
| 5 | 3TC+AZT | 58 |
| 6 | 3TC+AZT+IDV | 48 |
| 7 | D4T+NFV | 25 |
| 8 | DDC+NFV+RTV+SQV | 16 |
| 9 | 3TC+RTV+SQV | 5 |
| 10 | ABC+EFV+RTV+SQV | 44 |
| 11 | ABC+APV+D4T+RTV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I54V, I84V, L90M | L10FI, V11I, L33LF, G73S, L89V | I13IV, I15V, L19P, K20I, A22AV, E35G, M36I, I62V, L63P, A71I, P79A, I85IV |
| >CA11045| codons 1-99 PQITLWQRPFITVKVGGQPIEVLLDTGADDTIFEGINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKIISTVLVGATPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69A_VG, L210W, T215Y | A62V | S68G, K122E, I135T, T139I, S162Y, R211K, L228H, V245E |
| >CA10935| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKDGAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNEIPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQ |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |