<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1624 CA11023 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDC 104
2 3TC+AZT+IDV 26
3 3TC+AZT+RTV+SQV 74
4 D4T+DDI+RTV+SQV 57
5 ABC+D4T+EFV 23

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V L24I, L33F, F53L, G73C, N83D I15V, E34Q, M36L, N37NS, L38W, P39PS, R57K, D60E, I62V, L63P, A71V  
>CA11023| codons 1-99
PQITLWQRPLVTIKVGGQLKEALIDTGADDTVFQELSWSGRWKPKMIGGIGGLVKVKQYE
QVPIEICGHKVICTVLVGPTPVDIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219N L100I, K103N   T39A, E44D, V118VI, K122KE, H208Y, R211K, V245T, K277R, R284K, T286A, V292I, E297K  
>CA10933| codons 1-303
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGAKALTEIIPLTKEAE
LEL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005