Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1341 | CA11022 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDI | 100 |
| 3 | AZT+DDC | 40 |
| 4 | D4T | 26 |
| 5 | AZT | 38 |
| 6 | 3TC+AZT+IDV | 72 |
| 7 | 3TC+AZT+DLV+RTV+SQV | 38 |
| 8 | 3TC+ADV+AZT+EFV+NFV+SQV | 53 |
| 9 | ABC+ADV+EFV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | Q58E, G73T | L10I, L19I, R41K, I62V, L63P, A71I, V77I, I93L |
| >CA11022| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVREYD QVPIEICGHKIITTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219N | L100LI, K103N | V35VM, T39A, E44D, K122E, Q174R, G196E, Q197K, Q207E, R211K, Q278H, T286A, I293V |
| >CA10932| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIEKHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |