Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4518 | CA11008 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 265 |
| 2 | AZT+IDV | 57 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | DDI+DLV+NFV | 45 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215Y | K219Q | Y181C | T7TA, V35T, T39A, K101Q, K103R, D123E, I135V, S162C, G196E, E203D, V245T, I293V |
| >CA11008| codons 1-303 PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKRKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIDELRQHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | L10F | I15V, L19IT, K20I, M36I, R41K, K45R, L63P, A71V, I85V, Q92R |
| >CA11102| codons 1-99 PQITLWQRPFVTIKVGGQIIEALLDTGADDTVLEEINLPGKWKPRMIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPTNIVGRNLMTRIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |