<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4518 CA11008 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 265
2 AZT+IDV 57
3 3TC+D4T+IDV 52
4 DDI+DLV+NFV 45

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, T215Y K219Q Y181C   T7TA, V35T, T39A, K101Q, K103R, D123E, I135V, S162C, G196E, E203D, V245T, I293V  
>CA11008| codons 1-303
PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKRKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKIDELRQHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LEL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82T, L90M L10F I15V, L19IT, K20I, M36I, R41K, K45R, L63P, A71V, I85V, Q92R  
>CA11102| codons 1-99
PQITLWQRPFVTIKVGGQIIEALLDTGADDTVLEEINLPGKWKPRMIGGIGGFVKVRQYD
QIPIEICGHKVIGTVLVGPTPTNIVGRNLMTRIGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009