<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4517 CA11007 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 113
2 AZT+DDC 52
3 3TC+AZT 54
4 3TC+D4T+NVP+RTV 49
5 3TC+D4T+NVP+RTV+SQV 65
6 D4T+NVP+RTV+SQV 12

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M, F77L, K219N K101E, G190A   V35I, K43E, E44A, R83K, V118I, K122P, T139TI, I178L, G196E, Q207E, A272P, K275R, K277R, T286A, E297K V254VG, K281KI
>CA11007| codons 1-301
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDLRELNKKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSINNEIPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYVASDLEIEQHRTKIEELREHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTGNDIQKLVGKLNWASQIYPGIRVRQLCILLRGAKALTEVIPLTKEAE
L

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, V82A, I84V, L90M   L10I, I62V, L63H, A71V, V77I, I93L  
>CA11098| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFIKVRQYD
QVHIEICGHKVIGTVLIGPTPANVIGRNLMTQLGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005