Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4510 | CA10999 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NVP | 12 |
| 2 | NVP+3TC | 9 |
| 3 | 3TC+AZT+NFV | 15 |
| 4 | DDI+NFV+SQV | 5 |
| 5 | EFV+ABC+NFV+SQV | 49 |
| 6 | RTV+SQV | 10 |
| 7 | APV+RTV+SQV | 6 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, L210W | T215C, K219E | K101E, Y181I, G190A | V108I | E6D, T69N, K122E, I135M, S162C, E169D, Q174K, T200TA, D218E |
| >CA10999| codons 1-258 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKKNPDIVI IQYMDDLYVASDLEIGQHRAKIEELRQHLWRWGFCTPEEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, I84V | V11I | L10I, I13V, K20V, M36I, L63P, A71T, I72V |
| >CA11092| codons 1-99 PQITLWQRPIITVKIGGQLVEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKTVGTVLVGPTPTNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |