Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4503 | CA10991 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 43 |
| 2 | D4T | 43 |
| 3 | AZT | 21 |
| 4 | 3TC+AZT+IDV | 148 |
| 5 | DDI+NFV+NVP | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MV, L210W, T215Y | Y181C, G190A | K43Q, E44D, V60I, V118I, K122E, I142V, D177E, I178M, T200I, E203K, Q207E, R211K, K223Q, L228H, V245M, A272P, K277R, I293V, E297A |
| >CA10991| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYVDDLYVASDLEIGQHRIKIKELREHLWKWGFYTPDKKHQQEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IV, V82A | L24I, F53L | L10I, N37S, K55KR, L63P, A71V |
| >CA11083| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMSLPGRWKPKLIGGIGGLVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |