Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4486 | CA10967 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | D4T+ 3TC | 17 |
| 3 | 3TC+ D4T+ SQV | 30 |
| 4 | 3TC+ D4T+ IDV | 78 |
| 5 | DDI+ NFV+ NVP | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, V75T | A62V | Y181C | K20R, S48T, K49R, V90I, D123E, S162DN, E169D, R211RK, K223KE, L228LR, V245K, A272P, K277R, L283I, I293V, P294Q, E297K |
| >CA10967| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKITRIGPENPYNTPV FVIKKKDSTKWRKVTDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILDPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQEEPPFRWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVQLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | I15V, Q18H, K20I, E35D, M36I, P39S, I62V, L63P, A71V, I72L |
| >CA11056| codons 1-99 PQITLWQRPLVTIKVGGHLIEALLDTGADDTVLEDINLSGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVLSTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |