Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4485 | CA10966 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 56 |
| 2 | D4T | 12 |
| 3 | AZT | 39 |
| 4 | AZT+ 3TC | 12 |
| 5 | RTV+ 3TC+ AZT | 60 |
| 6 | NVP+ NFV+ D4T | 13 |
| 7 | SQV+ RTV+ DDI+ DLV | 89 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, D67N, Y115F, Q151M | V75I, F77L, F116Y, K219E | Y181C | K101HQ | S68G, D123E, I135V, S163SI, K166KR, R172RK, D177E, I202V, R211A, V245M, A272P, K277R, T286A, E297K |
| >CA10966| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKNGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAFYSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQSIMTRILEPFKKQNPEIVI CQYMDDLYVGSDLEIGQHRTKVEELRQHLLAWGFTTPDEKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L23LI, F53FL | L10I, K20R, E35D, M36I, D60E, L63P, A71V, I93L |
| >CA11055| codons 1-99 PQITLWQRPIVTIKIGGQLREAILDTGADDTVLEDINLPGRWKPKIIGGIGGLVKVRQYE QIPIEICGHKVIGTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |