Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4477 | CA10957 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ IDV | 120 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M, M184V | S68G, K122E, T200A, Q207E, F214FL, K277R, R284K, I293V, E297A, A304G, I329L, Q334N, R358RK, T369S, E370ED, I375IV, K390R, K395KR, V435A, D460N, L491EV, S519N, K527Q, A554AT |
| >CA10957| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLKGTKALTEVVPLTAEAE LELGENREILKEPVHGVYYDPSKDLIAELQKQGNGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLSDAVQKVATESIVIWGKTPKFRLPIQRETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIHLALQDSGVEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKEKVYLAWVPAHK GIGGNEQVDKLVSTGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10I, K20R, M36MI, N37D, R57K, D60E, Q61N, L63P, I93L |
| >CA11070| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFIKVKQYE NIPIEICGHKAIGTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |