Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3871 | CA10950 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 13 |
| 2 | AZT+DDC | 92 |
| 3 | 3TC+AZT+SQV | 16 |
| 4 | 3TC+D4T+IDV | 161 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | V108I | V35I, K43Q, E44D, V60I, V118I, K122E, D123N, I135M, G196E, H208Y, R211K, H221Y, A272P, I293IL, G335S, M357MT, A371V, I375V, A400T, E404D, V435E, K451R, D460N, S468P, H483HY, L491LQ, S519N, K530KR | E370EK |
| >CA10950| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DENFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVLPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTKVVQKVATESIVIWGKTPKFKLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIEGAETFYVDGAANRETRLGKAGYVTNRGRQKVVPLTDTTNQKTELQ AIYLALQDSGQEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82F | L10I, I13V, K14R, I15V, K20M, M36V, N37T, I62V, I64V, A71V, L89I |
| >CA11039| codons 1-99 PQITLWQRPIVTVRVGGQLMEALLDTGADDTVLEEVTLPGRWKPKMIGGIGGFAKVRQYD QVLVEICGHKVIGTVLVGPTPFNIIGRNILTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |