<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4465 CA10939 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 Unknown NA
2 3TC+AZT+SQV 12
3 3TC+NFV+SQV 35
4 3TC+DDI+NVP 8
5 3TC+AZT+RTV+SQV 8
6 ABC+D4T+Unknown 58

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   K103N, Y181C   K20R, K43E, E44D, S48T, A98S, V118I, K122E, D123E, S162A, D177E, T200A, R211RK, D218E, A272P, K277R, I293V  
>CA10939| codons 1-293
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEDGKITKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI
CQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVV

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46ML, I54V, V82A, L90M   T4P, L10I, G16E, K20R, E35D, M36I, R41K, Q61HN, I62V, L63H, A71V, I93L  
>CA11030| codons 1-99
PQIPLWQRPIVTIKIEGQLREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYD
HVHIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005