Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4465 | CA10939 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | NA |
| 2 | 3TC+AZT+SQV | 12 |
| 3 | 3TC+NFV+SQV | 35 |
| 4 | 3TC+DDI+NVP | 8 |
| 5 | 3TC+AZT+RTV+SQV | 8 |
| 6 | ABC+D4T+Unknown | 58 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K103N, Y181C | K20R, K43E, E44D, S48T, A98S, V118I, K122E, D123E, S162A, D177E, T200A, R211RK, D218E, A272P, K277R, I293V |
| >CA10939| codons 1-293 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEDGKITKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54V, V82A, L90M | T4P, L10I, G16E, K20R, E35D, M36I, R41K, Q61HN, I62V, L63H, A71V, I93L |
| >CA11030| codons 1-99 PQIPLWQRPIVTIKIEGQLREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYD HVHIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |