Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4375 | CA10788 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 25 |
| 2 | AZT+3TC | 21 |
| 3 | D4T+3TC+IDV | 56 |
| 4 | 3TC+AZT+DDI+IDV+NVP | 12 |
| 5 | D4T+DLV+NFV+SQV | 107 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84V, L90M | K43T | L10I, E35DN, M36I, F53Y, I62V, L63Q, I64V, A71V, I93L |
| >CA10788| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWTPKIIGGIGGYVKVRQYD QVQVEICGHKVIGTVLVGPTPFNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103N, Y188L | K20R, E44D, V60I, K102N, V118I, K122E, I142V, Q197E, T200A, I202V, H208Y, V245E |
| >CA10578| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKNNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGEHRAKVEELRQYLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |