Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1148 | CA10769 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI+ AZT | 91 |
| 3 | SQV+ D4T+ 3TC | 30 |
| 4 | IDV+ DDI+ AZT | 27 |
| 5 | SQV+ RTV | 8 |
| 6 | SQV+ RTV+ AZT+ 3TC | 59 |
| 7 | SQV+ RTV+ D4T+ AZT+ 3TC | 10 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54V, V82AS, L90M | F53L | L10I, L33M, E34Q, N37H, R57RK, Q61E, L63E, I64V, E65D, A71V |
| >CA10769| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTIMQEMHLPGRWKPKMIGGIGGLVKVKQYD EIEVDICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | K20R, E44D, V60I, K122KE, D123E, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293V |
| >CA10560| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEKHRTKIDELRQFLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDIWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |