Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA1581 | CA10737 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 30 |
2 | SQV | 21 |
3 | 3TC+ SQV | 8 |
4 | 3TC+ D4T+ SQV | 12 |
5 | 3TC+ DDI+ D4T+ SQV | 13 |
6 | 3TC+ DDI+ IDV+ D4T+ SQV | 28 |
7 | 3TC+ DDI+ SQV+ NVP+ IDV | 12 |
8 | 3TC+ NFV+ SQV | 34 |
9 | DDI+ SQV+ RTV | 11 |
10 | DDI+ ABC+ EFV+ SQV+ RTV | 27 |
11 | DDI+ ABC+ ADV+ SQV+ RTV | 21 |
12 | None | 8 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
L10I, K43R, D60DE, Q61E, I62V, L63Q, C67Y, A71V, V77I, I93L |
>CA10737| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYE EVQIEIYGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
T215Y | G196DE, R211G, A272P, K277R, T286A, E297K |
>CA10528| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIDQHRTKIEELRQHLLGWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKE |
References
Author | Title | Citation |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |