Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1581 | CA10737 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 30 |
| 2 | SQV | 21 |
| 3 | 3TC+ SQV | 8 |
| 4 | 3TC+ D4T+ SQV | 12 |
| 5 | 3TC+ DDI+ D4T+ SQV | 13 |
| 6 | 3TC+ DDI+ IDV+ D4T+ SQV | 28 |
| 7 | 3TC+ DDI+ SQV+ NVP+ IDV | 12 |
| 8 | 3TC+ NFV+ SQV | 34 |
| 9 | DDI+ SQV+ RTV | 11 |
| 10 | DDI+ ABC+ EFV+ SQV+ RTV | 27 |
| 11 | DDI+ ABC+ ADV+ SQV+ RTV | 21 |
| 12 | None | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K43R, D60DE, Q61E, I62V, L63Q, C67Y, A71V, V77I, I93L |
| >CA10737| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYE EVQIEIYGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | G196DE, R211G, A272P, K277R, T286A, E297K |
| >CA10528| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIDQHRTKIEELRQHLLGWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |