Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4299 | CA10690 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 56 |
| 2 | D4T | 35 |
| 3 | 3TC+AZT+IDV | 74 |
| 4 | D4T+NFV+NVP | 48 |
| 5 | 3TC+D4T+NFV | 26 |
| 6 | 3TC+AZT+EFV+NFV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L33I, G73S | L10I, K14R, L19I, K20I, M36I, R41RK, L63P, I64V, A71V, I93L |
| >CA10690| codons 1-99 PQITLWQRPIVTIRIGGQIIEALLDTGADDTVIEEINLPGKWKPKIIGGIGGFIKVRQYD QIPVEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74LV, M184V, L210W, T215Y | K101E, Y181C, G190A | V108I | E28K, K122E, D123E, I132X, P133X, I135T, D177E, V179I, H208Y, H221Y, R284K, T286A, I293V |
| >CA10486| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSVPL DEEFRKYTAFTXXSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYVDDLYVASDLEIGQHRTKIEELRQYLWRWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |