Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA622 | CA10676 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 18 |
| 2 | AZT+DDC | 4 |
| 3 | AZT+DDI | 13 |
| 4 | 3TC+AZT | 44 |
| 5 | 3TC+D4T+IDV | 22 |
| 6 | D4T+DDI+IDV | 32 |
| 7 | 3TC+D4T+RTV+SQV | 58 |
| 8 | ADV+EFV+RTV+SQV | 8 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, I84V, L90M | G73S | L10I, N37ND, R41K, K45KR, L63P, A71LV, V77I, I85V, I93L |
| >CA10676| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGKWKPRIIGGIGGFIKVRQYD QIPIEICGHKLISTVLIGPTPTNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, L210W | K219E | G190S | V35I, E44D, L109LI, V118I, K122E, I202V, H208Y, R211K, T215X, T216X, L228H | M230MV |
| >CA10470| codons 1-239 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKVEELRQYLWKWGFXXPDEKHQKEPPFHWVGYELHPDKW |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |