Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4423 | CA10634 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 61 |
| 2 | 3TC+AZT | 17 |
| 3 | 3TC+AZT+IDV | 87 |
| 4 | 3TC+DDI+IDV | 52 |
| 5 | D4T+DDI+EFV+NFV | 12 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, M184V, T215F | K219Q | G190S | E6D, K20R, K49R, K64R, V118I, D123E, I135T, T139K, I178L, T200S, H208Y, R211K, F214L, V245VE |
| >CA10634| codons 1-254 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIRKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVSSDLEIGQHRSKIEELRQYLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L24I, G73ST | I3IF, L10I, I15V, G17E, E34A, E35D, M36I, R41K, K55KR, I62V, L63P, I66IM, I72IM |
| >CA10828| codons 1-99 PQFTLWQRPIVTIKVGEQLKEALIDTGADDTVLADINLPGKWKPKIIGGIGGFIRVRQYD QVPIEMCGHKAMSTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |