Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1441 | CA10632 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 122 |
| 2 | AZT+ DDI | 104 |
| 3 | 3TC+ DDI+ AZT | 61 |
| 4 | AZT+ DDI+ RTV | 26 |
| 5 | AZT+ DDI+ IDV+ NVP | 77 |
| 6 | 3TC+ D4T+ ABC+ EFV+ SQV+ NFV | 52 |
| 7 | D4T+ 3TC+ ABC+ NFV+ SQV | 7 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, T215F | K219Q | K101E, Y181C, G190S | K20R, V35M, T39E, T69N, R83K, I167V, I202V, D218E, L228H, V245K, D250E, K277R, T286A, E297K |
| >CA10632| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICEELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKITDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPDIVI CQYVDDLYVSSDLEIGQHRTKVEELRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | F53FL, Q58E | L10I, I15V, K20R, E35D, M36I, N37E, W42Y, K55R, R57K, I62V, L63P, A71V |
| >CA10841| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRYKPKLIGGIGGLVRVKEYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |