Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4420 | CA10629 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 65 |
| 2 | D4T+ 3TC+ NFV | 47 |
| 3 | ADV+ NVP+ IDV | 13 |
| 4 | ADV+ ABC+ IDV+ NVP | 30 |
| 5 | NVP+ IDV+ ABC | 21 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, V75M, L210W, T215Y | K101E, K103N, Y181C | E28K, T39TA, K43E, E44A, K104R, V118I, K122E, G196E, E203V, Q207E, H208Y, R211K, R284K, I293V, E297A |
| >CA10629| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKIMDFRELNKRTQDFWEVQLGIPHPAGLEKNRSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIVELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVPLTAEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | Q58E, G73S | L10I, I62V, L63P, H69Y, A71V, I72E, V77I, I93L |
| >CA10831| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QVPIEICGYKVESTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |