Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4414 | CA10622 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 12 |
| 2 | AZT+ 3TC | 9 |
| 3 | DDI+ D4T+ NVP | 24 |
| 4 | D4T+ NVP | 43 |
| 5 | D4T+ EFV+ SQV | 12 |
| 6 | D4T+ EFV+ SQV | 19 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | K103N, Y181C | K238KT | D17G, T27S, E42EG, K49R, V60I, R83RK, V90I, D123E, I135LV, D177E, R211K, T240TA |
| >CA10622| codons 1-246 PISPIETVPVKLKPGMGGPKVKQWPLSEEKIKALVEICTEMGKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDTWA VQPIVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, N37D, D60E, L63S |
| >CA10829| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QISIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |