Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4345 | CA10543 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | D4T+IDV | 48 |
| 3 | 3TC+NFV | 65 |
| 4 | RTV+SQV | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184MV | T215D | K20R, E44D, S68SG, V90VI, V118I, A158AP, A272P, V292I, E300EQ | N265ND, E291DV |
| >CA10543| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPPIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFDTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLDWASQIYPGIKVKQLCKLLRGTKALTDIIPLTEEAQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48Q, I54T, V82F, L90M | K43T | L10I, E35D, M36I, N37D, I62V, L63T, I72V, V77I, L89M, I93L |
| >CA10753| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDIDLPGRWTPKIIQGIGGFTKVRQYD QVTIEICGHKAVGTVLIGPTPFNIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |