Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4341 | CA10537 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 83 |
| 2 | D4T+DDI+NFV | 91 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | V60I, V90I, K104N, I142V, S162Y, E203ED, R211K |
| >CA10537| codons 1-259 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIDELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | K20I, E35D, M36MI, I64V, A71AV |
| >CA10747| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKVIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |