Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4333 | CA10525 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+DDI | 30 |
| 3 | AZT+D4T | 39 |
| 4 | 3TC+AZT+D4T+IDV | 74 |
| 5 | 3TC+AZT+NFV | 74 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K20R, V21I, T39K, K43E, E44D, V60I, K104N, V118I, K122E, I135V, I202V, R211K |
| >CA10525| codons 1-256 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVND |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T | L24I, Q58E | L10I, K20I, M36V, L63P, I64V, A71V, I93L |
| >CA10734| codons 1-99 PQITLWQRPIVTIKIGGQLIEALIDTGADDTVLEEVNLPGRWKPKIIGGIGGFIKVREYD QIPVEICGHKVIGTVLVGPTPTNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive value of HIV-1 genotypic resistance test interpretation algorithms. | J Infect Dis, 2009 |