Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4328 | CA10519 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 104 |
| 2 | NRTI | 52 |
| 3 | AZT+DDC | 52 |
| 4 | 3TC+D4T | 52 |
| 5 | NRTI | 52 |
| 6 | 3TC+AZT+IDV | 25 |
| 7 | 3TC+AZT+DDI+NVP | 4 |
| 8 | 3TC+AZT+DDI+RTV+SQV | 47 |
| 9 | D4T+DDI+NVP | 26 |
| 10 | 3TC+ABC+D4T+IDV+RTV | 18 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, M184V, L210W, T215Y | Y181C | D17DG, E44D, V60I, V111X, K122E, S134SC, S162D, E169D, H208Y, R211K | Y144YS |
| >CA10519| codons 1-252 PISPIETVPVKLKPGMGGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDXGDAYFSVPL DEDFRKYTAFTIPCINNETPGIRSQYNVLPQGWKGSPAIFQDSMTKILDPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10F, L33I, G73S | T4A, L19I, E35D, M36I, R57K, L63P, A71V, I72F, I85V |
| >CA10728| codons 1-99 PQIALWQRPFVTIKIGGQIKEALLDTGADDTVIEDINLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKVFSTVLVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |