Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4291 | CA10476 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 13 |
| 2 | AZT+ DDC | 26 |
| 3 | 3TC+ AZT | 52 |
| 4 | D4T+ DDI+ NFV | 70 |
| 5 | D4T+ DDI | 42 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, T215F | K219Q | K20R, Q23X, V60I, K103R, V118I, I135T, G196E, R211G, F214L |
| >CA10476| codons 1-267 PISPIETVPVKLKPGMDGPRVKHWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLGWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L90LM | K20I, N37DH, D60E, L63P |
| >CA10682| codons 1-99 PQITLWQRPLVTIKIGGQLIEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYE QIPIEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |