Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1165 | CA10420 | U.S. | 1996 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDC | 52 |
| 3 | D4T | 52 |
| 4 | 3TC+AZT+SQV | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, T69D, M184V, T215Y | K219KR | K20R, V60I, V118I, K122E, I135M, G196E, F214FL, L228H, N255NH |
| >CA10420| codons 1-286 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLYTPDRKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVHDIQKLVGKLNWASQIYAGIKVKQLCKLLRGT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54IV, L90LM | L10I, T12P, K14R, E35D, N37D, L63P, C67D |
| >CA10421| codons 1-99 PQITLWQRPIVPIRIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIVGIGGFVKVRQYD QIPIEIDGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Lawrence, J | Clinical resistance patterns and responses to two sequential protease inhibitor regimens in saquinavir and reverse transcriptase inhibitor-experienced persons. | J Infect Dis, 1999 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |