Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JL-Pt11 | JL-11-post | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+DDC | NA |
| 3 | 3TC+D4T+SQV | 35 |
| 4 | D4T+DDI+NFV | 17 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, I13IM, E35D, M36I, N37S, R41K, I62V, L63P, A71V, I93L |
| >JL-11-post| codons 1-99 PQITLWQRPIVTMKIGGQLKEALLDTGADDTVLEDISLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, Q151M, T215Y | K70S, V75I, F116Y | T58S, D121H, K122E, I135V, D177E, Q242X | F77V |
| >JL-11-post| codons 1-248 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNSPV FAIKKKNSTSWRKLIDVRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL HEDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VHPIVLPE |
References
| Author | Title | Citation |
| Lawrence, J | Clinical resistance patterns and responses to two sequential protease inhibitor regimens in saquinavir and reverse transcriptase inhibitor-experienced persons. | J Infect Dis, 1999 |
| Winters, MA | Human immunodeficiency virus type 1 protease genotypes and in vitro protease inhibitor susceptibilities of isolates from individuals who were switched to other protease inhibitors after long-term saquinavir treatment. | J Virol, 1998 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |