Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML1990 | ML1990 | Kenya | 2002 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, V31I, S39C, M50I, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, Q216H, N254K | S283G, R284G |
| >ML1990| codons 1-288 FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVACCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKHITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDKSDIKVVPRRKAKIIRDYGKQMAGDDCVAGGQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, K14R, K20R, E35D, M36I, N37D, R41K, R57K, D60E, C67Y, H69K, L89M |
| >ML1990| codons 1-99 PQITLWQRPIVTVRIGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYE QILIEIYGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E40D, K49R, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245Q, D250E, E291D, V292I, I293V, P294T, E312D, I326M, G335D, M357K, G359S, K366R, T369A, A371V, I375V, A376V, T377M, A400T, E404D, E432D, V435A, D471E, Q480H, L491S, S519N, Q524K, K527E, E529D, A534S, A554K |
| >ML1990| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTDMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLMAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVRQLAEVVQKVVMESIVIWGKTPKFKLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEKLIEKDKVYLSWVPAHK GIGGNEQVDKLVSKGIRKVL |
References
| Author | Title | Citation |
| Land, AM | Full-length HIV type 1 proviral sequencing of 10 highly exposed women from Nairobi, Kenya reveals a high proportion of intersubtype recombinants. | ARHR, 2008 |